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In a gloomy mansion in the west of Scotland the seven members of the Good Comrades Club are dining. One of them receives a curious death threat, an envelope containing seven orange pips. He dies the next night in a car crash. At his funeral another member receives an envelope with six pips, and ten days later his body is recovered from the sea. Sherlock Holmes is called in.

In order to escape from the abusive boy-friend, Gary Winston (Damian Lewis), Jean Gilkyson (Jennifer Lopez) moves with her young daughter Griff Gilkyson (Becca Gardner) without previous notice to the ranch of her father-in-law Einar Gilkyson (Robert Redford) in Wyoming. Jean and Einar are disaffected, since he blames her for the death of his beloved son in a car accident. Einar is taking care of his friend Mitch Bradley (Morgan Freeman), who was attacked and seriously wounded by a bear, and he does not know that he has a grand-daughter. While Mitch heals his wounds and forgives the bear, Einar also changes his feelings regarding Jean, finally understanding that accidents happen and accepting her and loving his grand-daughter.

After her divorce, Meg Altman and her daughter Sarah move into an old-fashioned house with one very modern addition: a “panic room” which is virtually impossible to break into, designed for refuge during a home invasion. In their first night in the house a trio of thieves do break in and Meg and Sarah rush into the panic room. However, the intruders are looking for something inside the panic room, and given the recent move the room’s hotline to the police hasn’t been hooked up yet. Worse, Sarah is diabetic and the room doesn’t contain any sugar…

A war has been raging between the Vampires and Lycan for centuries, Selene (Beckinsale) is a death dealer, assigned to hunt down and eradicate the last of the Lycan. When she comes across Michael Corvin(Speedman)who holds the key to end the war she must decide where her alligances will lie.