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When a pearl with a sinister reputation for causing misfortune to its owners is stolen from a museum by a master criminal because of Sherlock Holmes’ show-boating, he is naturally obliged to find it. Soon, he learns of a series of brutal murders that seemed to have been commited by a malevolent man mountain known only as the Creeper. Now, Holmes must deal with the seemingly overwhelming menace of this man and his boss in order to retrieve the pearl.

Holmes and Watson investigate a series of bizarre and apparently unconnected murders, and the death of a possible suspect. The trail leads to a society of hypnotists and a mysterious, glamoruos woman. The fiendish Dr Moriarty, though reported hanged in Montevideo, is belived to be involved.

Alarmed by a series of baffling suicides of prominent gamblers popularly dubbed “The Pajama Murders” by the newspapers, Holmes fakes his own death and assumes the identity of Rajni Singh, a retired Indian military man with a paralyzed arm. After losing a large sum in a casino and writing a bad check to cover his losses, he appears to try to take his own life. He is prevented by the mysterious and sophisticated Andrea Spedding with an offer of a loan with his life insurance policy as collateral. Shortly thereafter, there is an attempt on his life with a rare but deadly spider with the only other clue a child’s footprint. A resurfaced Holmes consults arachniolgists in an effort to solve the mystery.