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When a pearl with a sinister reputation for causing misfortune to its owners is stolen from a museum by a master criminal because of Sherlock Holmes’ show-boating, he is naturally obliged to find it. Soon, he learns of a series of brutal murders that seemed to have been commited by a malevolent man mountain known only as the Creeper. Now, Holmes must deal with the seemingly overwhelming menace of this man and his boss in order to retrieve the pearl.

Alarmed by a series of baffling suicides of prominent gamblers popularly dubbed “The Pajama Murders” by the newspapers, Holmes fakes his own death and assumes the identity of Rajni Singh, a retired Indian military man with a paralyzed arm. After losing a large sum in a casino and writing a bad check to cover his losses, he appears to try to take his own life. He is prevented by the mysterious and sophisticated Andrea Spedding with an offer of a loan with his life insurance policy as collateral. Shortly thereafter, there is an attempt on his life with a rare but deadly spider with the only other clue a child’s footprint. A resurfaced Holmes consults arachniolgists in an effort to solve the mystery.

Holmes is hired by Roland Carstairs to prevent the theft of the Star of Rhodesia, an enormous diamond owned by Carstairs’ mother, Lady Margaret. Believing the diamond will be stolen on a train trip from London to Edinburgh, Holmes deftly switches diamonds with Lady Margaret while in her compartment. Soon after, Roland is murdered and the fake diamond is stolen. Red herrings abound as Holmes, aided by Dr. Watson and Inspector Lestrade, discover the murderer’s hiding place and deduce that long-time foe Moriarty’s henchman Colonel Sebastian Moran is somehow involved in the crime.

In a gloomy mansion in the west of Scotland the seven members of the Good Comrades Club are dining. One of them receives a curious death threat, an envelope containing seven orange pips. He dies the next night in a car crash. At his funeral another member receives an envelope with six pips, and ten days later his body is recovered from the sea. Sherlock Holmes is called in.